Xun Gu
Professor
Dr. Gu, Professor. He came to Iowa State University as an Assistant Professor in 1998, and was promoted to Associate Professor (with tenure) in 2002, and to Full Professor (with tenure) in 2006. Dr. Gu serves on the editorial board of “Molecular Phylogenetics and Evolution”, and “Journal of Experimental Zoology B”. Dr. Gu is the 2001 recipient of the prestigious Dupont Young Professor Award. Dr. Gu’s research group has focused on comparative and evolutionary genomics, computational biology, and evolution of systems biology. Dr. Gu and his group have published over 100 papers.
Research Description
His research has been focused on (1) statistical methods for evolutionary genomics for understanding the genome complexity, and (2) high throughput comparative genomics analysis. Achievements of our research group are: Develop statistical methods and bioinformatics software for predicting functional divergence of a protein family, statistical analysis for expression divergence between duplicate genes, and statistical modeling for gene gain and loss during genomic evolution. Analyze across-species model organism genomes, from yeasts, plants, vertebrates to primates. Recently, our research is exploring the new area of Systems Biology and Evolution: Understanding gene pleiotrophy, genetic robustness, genome complexity and gene network evolution.
Contact Information
536 Science Hall II
Ames, IA 50011-3220
515-294-8075 voice
515-294-8457 fax
Education
B.Sc., Fudan University, China, 1985
M.Sc., Fudan University, China, 1987
Ph.D., University of Texas, Houston, 1996
Publications
- H Lin, G Moghe, S Ouyang, A Iezzoni, S-H Shiu, X Gu, C. R Buell. 2010. Comparative analyses reveal distinct sets of lineage-specific genes within Arabidopsis thaliana. BMC Evol Biol 10:41 .
- H Zhang, R Hemasinha, Xun Gu. 2010. A Statistical Model and Algorithm for Genome Phylogeny Accommodating Lateral Gene Transfer. Inter J Synthetic Systems biol (IJSSB) In press.
- X Wang, Y Huang, D V Lavrov and X Gu. 2009. Comparative study of human mitochondrial proteome reveals extensive protein subcellular relocalization after gene duplications. BMC Evol Biol 9:275.
- Y Huang , Y Zheng, Z Su, X Gu. 2009. Differences in duplication age distributions between human GPCRs and their downstream genes from a network prospective. BMC Genomics 10(Suppl 1):S14.
- Y Zou, Z Su, J Yang, Y Zeng and X Gu. 2009. Uncovering Genetic Regulatory Network Divergence between Duplicate Genes Using Yeast eQTL Landscape. JEZ-B: Mol Dev Evol 312B:722-733.
- B Mertz, X Gu, P J. Reilly. 2009. Analysis of Functional Divergence within Two Structurally Related Glycoside Hydrolase Families. Biopolymer 91:479-495.
- X Gu and Y Huang. 2009. Expansion of Duplicated MicroRNAs and Protein-coding Genes during a Broad Time Window of Early Vertebrates. JEZ-B: Mol Dev Evol 312B:164-170.
- Z Su, L Xu, Z Gu and X Gu. 2009. Origins of digestive RNases in leaf monkeys are an open question. Mol Phylogene Evol 53:610-611.
- L Xu, Z Su; Z Gu, and X Gu. 2009. Evolution of RNases in Leaf Monkeys: Being Parallel Gene Duplications or Parallel Gene Conversions is a Problem of Molecular Phylogeny. Mol Phylogene Evol 50:397-400.
- X. Gu. 2009. An Evolutionary Model for the Origin of Modularity in a Complex Gene Network. JEZ-B: Mol Dev Evol 312:75-82.
- Q Cheng, Z Su, Y Zhong and X Gu. 2009. Effect of site-specific heterogeneous evolution on phylogenetic reconstruction: A simple evaluation. Gene 441:156-182.
- H Zhang, Y Zhong, B Hao and X Gu. 2009. A simple method for phylogenomic inference using the information of gene content of genomes. Gene 441:163-168.
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