Speaker: Duc Dong, Sanford Burnham Prebys Medical Discovery Institute associate dean of admissions, Graduate School of Biomedical Sciences, and associate professor, Human Genetics Program 

Title: "Augmented regeneration: kicking it up a Notch"

Abstract: My research combines genetics and chemical biology with cell and animal models to investigate developmental disorders, organogenesis, and regeneration, with the goal of making fundamental discoveries that we can leverage to augment human health. Our recent discoveries have yielded insight into how Notch signaling, autophagy, and cellular plasticity can be modulated as approaches to enhance regeneration, and longevity. We have developed a Notch signaling agonist to stimulate liver regeneration in children with Alagille Syndrome, a Jagged/Notch haploinsufficient disorder. This first-in-class drug directly targets the Notch receptor in patient cells and can rescue regenerative failure in animal models of Alagille Syndrome. As the first Notch agonist small molecule, broad potential applications for other implications, such as cancer and degenerative diseases, will be also discussed. In separate project, we aim to generate replacement cells directly in the body, by hacking into other cell types and reprogramming them to transdifferentiate, bypassing inherent risks associated with stem cells, transplantations, and immunosuppressant drugs. Mechanistic studies reveal that active repression of the endogenous cell identity, as well as induction of the cell recycling process autophagy, is necessary, and can enhance, reprogramming efficiency. My vision is to advance our proof-of-concept therapeutic strategies into practical applications, not only to treat diseases and injuries, but to also enhance human performance.

Host: Clyde Campbell, adjunct assistant professor in genetics, development and cell biology

Lab: http://labs.sbpdiscovery.org/centerandlabs/childrenshealth/donglab/Pages/Home.aspx

Jan. 25, 2022, GDCB Seminar: Duc Dong