Speaker: Keisuke Ito, professor at Albert Einstein College of Medicine in the departments of Cell Biology, Medicine, and Oncology (Medical Oncology); and director of scientific resources in the Stem Cell Institute

Title: "Mitochondrial contributions to hematopoietic homeostasis and the pathogenesis of hematological disorders"

Abstract: Mitochondria play a crucial role in utilizing various pathways to meet cellular energy demands. However, the intricate mechanisms by which mitochondrial metabolism influences the fate of hematopoietic stem cells (HSCs) remain elusive. At the Ito Lab, we are dedicated to elucidating the regulatory pathways that maintain the balance between healthy and malignant HSCs. In this presentation, I will provide an overview of our research efforts, highlighting our progress in understanding how mitochondria and lipid metabolism shape HSC fate determination. We believe that gaining deeper insights into metabolic regulation will not only refine HSC transplantation techniques but also open doors to innovative therapeutic strategies for hematological disorders.

Hosts: Raquel Espin Palazon and Clyde Campbell, genetics, development and cell biology assistant professors