Dr. Malene Hansen, Sanford Burnham Prebys (SBP) Medical Discovery Institute, Program for Development, Aging and Regeneration, La Jolla, Calif., professor; SBP Graduate School of Biomedical Sciences, associate dean of student affairs; and faculty advisor of postdoctoral training in La Jolla.

Title — Autophagy and aging: Lessons from long-lived C. elegans

Abstract: The cytosolic recycling process of autophagy plays an important role in many age-related diseases and has been directly linked to aging, including in the nematode C. elegans where autophagy appears beneficially induced in many conserved longevity models. As a critical process to ensure cellular homeostasis, autophagy is regulated at multiple levels, yet it remains a challenge in the field to understand how the regulation of autophagy is integrated at the cellular and molecular level to ensure health- and lifespan benefits. I will here discuss our progress on understanding the different molecular mechanisms employed by cells and organisms to regulate autophagy in response to stressors such as aging and disease.

Refreshments will be served prior to the GDCB Seminar at 3:45 p.m.

Host: Hua Bai