GDCB Special Seminar: 'Transposable element contributions to programming novel expression variation'

Thursday, February 14, 2019 - 4:10pm
Event Type: 

Sarah AndersonSpeaker — Sarah Anderson, Postdoctoral Associate in the University of Minnesota, Twin Cities, Department of Plant and Microbial Biology

Title — Transposable element contributions to programming novel expression variation

Abstract — I am interested in understanding how dynamic gene regulatory variation arises within genomes. Transposable elements (TEs) comprise the majority of large crop genomes and are a major source of genetic variation among individuals. A survey of TE variability across four assembled maize genomes reveals over 1.6 Gb of variable TE sequences, with over half of all maize genes near a TE that is variable among genotypes. We have shown that these variable TEs have the potential to influence transcriptomes through several mechanisms, including introducing novel regulatory elements, altering epigenetic state, and through acting as a source of gene content variation. By combining TE variation analyses with systems biology approaches, I can begin to monitor the roles that TEs play in rewiring transcriptional networks.

Host — Drena Dobbs