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Building a DNA nanoparticle to be both carrier and medicine

Eric Henderson, Department of Genetics, Development and Cell Biology professor
Eric Henderson in his lab, where the professor of genetics, development and cell biology worked with doctoral student Chang-Yong Oh to create a DNA nanoparticle capable of expressing its own genetic code. Photo by Christopher Gannon.

AMES, Iowa — Scientists have been making nanoparticles out of DNA strands for two decades, manipulating the bonds that maintain DNA’s double-helical shape to sculpt self-assembling structures that could someday have jaw-dropping medical applications.

Study of DNA nanoparticles, however, has focused mostly on their architecture, turning the genetic code of life into components for fabricating miniscule robots. A pair of Iowa State University researchers in the genetics, development and cell biology department – professor Eric Henderson and recent doctoral graduate Chang-Yong Oh – hope to change that by showing nanoscale materials made of DNA can convey their built-in genetic instructions. 

Visit ISU News Service's article, "Building a DNA nanoparticle to be both carrier and medicine," to read the complete article.

Henderson's research is featured in a "We Are Iowa" Local 5 News story, "A genetic cure": Iowa State scientists make first-of-its-kind DNA discovery."