Dr. Geetu Tuteja received her B.A. in Computer Science with a minor in Chemistry from Boston University in 2004 and her Ph.D. in Genomics and Computational Biology in the Department of Genetics, the University of Pennsylvania in 2009. From 2010 to 2015, Dr. Tuteja was a postdoctoral research fellow with Professor Gill Bejerano of Stanford University’s Beckman Center, within the Department of Developmental Biology, in Stanford, California.
Dr. Tuteja joined the GDCB faculty in July 2015 as a tenure-eligible assistant professor and a Gregory L. and Kathleen C. Geoffroy Faculty Fellow. This three-year fellowship was awarded by the College of Liberal Arts and Sciences to Dr. Tuteja as part of her new faculty appointment and is awarded at the discretion of the dean and designed to attract the very best junior faculty to the college.
Our lab is broadly interested in transcriptional regulation, which is directed in part by the binding of sequence-specific transcription factors (TFs) to enhancer regions. Identifying cell-type specific enhancers is crucial for understanding the genetic architecture underlying development and disease. Currently we are studying the molecular mechanisms underlying trophoblast invasion, a process that occurs in early placental development and establishes adequate blood flow between mother and fetus. Defects in trophoblast invasion can lead to a number of disorders, such as preeclampsia, intrauterine growth restriction, and placenta creta.
We are applying next-generation sequencing technologies to identify enhancers and transcription factor binding events specific to the process of trophoblast invasion using the mouse model. We use computational approaches to analyze and integrate our data sets, and to construct gene-enhancer networks. Finally, we test functionality of the gene enhancer network components using mouse and human cell lines. Ultimately, we hope that our findings will translate to early detection and prevention of common and serious placental disorders.
Publications – PubMed
- Tuteja G, Chung T, Bejerano G (submitted, 2015). Changes in the enhancer landscape during early placental development uncover a trophoblast invasion gene-enhancer network.
- Tuteja G, Moreira KE, Wenger AM, Chung T, Chen J, Bejerano G (2014). Automated discovery of tissue-targeting enhancers and transcription factors from binding motif and gene function data. PLoS Computational Biology; 10(1): e1003449.
- Wenger AM, Clarke SL, Notwell JH, Chung T, Tuteja G, Guturu H, Schaar BT, Bejerano G (2013). The enhancer landscape during early neocortical development reveals patterns of dense regulation and co-option. PLoS Genetics; 9(8):e1003728.
- Tuteja G, Cheng E, Papadakis H, Bejerano G (2012). PESNPdb: A comprehensive database of SNPs studied in association with pre-eclampsia. Placenta; 33(12):1055-1057.
- Li Z, Gadue P, Chen K, Jiao Y, Tuteja G, Schug J, Li W, Kaestner KH (2012). Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell; 151(7):1608-1616.
- Li Z, Tuteja G, Schug J, Kaestner KH (2012). Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer. Cell; 148(1):72-83.
- Tuteja G (2012). DNA-protein Interaction analysis (ChIP-Seq). In Bioinformatics for Next Generation Sequencing. Springer; 127-149.
- Li Z, Schug J, Tuteja G, White P, Kaestner KH (2011). The nucleosome map of the mammalian liver. Nat Struct Mol Biol; 18(6):742-6.
- Soccio RE*, Tuteja G*, Everett L, Lazar MA, Kaestner KH (2011). Species-specific strategies underlying conserved functions of metabolic transcription factors. Mol Endocrinol; 25(4):694-706. * Contributed equally to this work
- Lefterova MI, Steger DJ, Zhuo D, Qatanani M, Mullican SE, Tuteja G, Manduchi E, Grant GR, and Lazar MA (2010). Cell Specific Determinants of PPARg Function in Adipocytes and Macrophages. Mol. Cell. Biol.; 24(10):1035-44.
- Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH (2009). CRTC2 Contributes to the Transcriptional Response to Fasting in the Liver but is Not Required for the Maintenance of Glucose Homeostasis. Cell Metabolism; 10(1):55-62.
- Tuteja G, White P, Schug, J, Kaestner KH (2009). Extracting transcription factor targets from ChIP-Seq data. Nucleic Acids Research; 37(17):e113.
- Li Z, White P, Tuteja G, Sackett S, Kaestner KH (2009). Foxa1 and Foxa2 control bile duct development. Journal of Clinical Investigation; 119(6):1537-1545.
- Tuteja G, Jensen ST, White P, Kaestner KH (2008). Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site. Nucleic Acids Research; 36(12):4149-57.
- Tuteja G, Kaestner KH (2007). Forkhead transcription factors II. Cell. 131(1):192.
- Tuteja G, Kaestner KH (2007). Forkhead transcription factors I. Cell. 130(6):1160.