Structure, function and activity of the genome

GDCB has notable expertise in both experimental and computational approaches. The field of genome dynamics includes vital processes required for the maintenance, inheritance and expression of the genetic material; including transcriptional and post-transcriptional regulation of gene expression, segregation and recombination of genetic material, transposition, and mechanisms of genome evolution. ISU and the GDCB department have expertise in a number of these areas, most notably in the experimental analysis of gene expression, transposition, and recombination and the analysis of genome structural data using bioinformatics and computational biology approaches. These computational tools are enabling rapid advances in a number of important areas, including gene discovery and function prediction, analysis and prediction of regulatory signals in DNA, comparative genomics and molecular phylogeny, and global analyses of gene expression patterns and protein-protein interactions involved in cellular and developmental processes. Ultimately, this research provides the basis for successful modeling of genetic, metabolic and signal transduction networks.